Posted by poser938 on January 12, 2013, at 13:27:08
In reply to Re: Pooped out SSRI - No discontinuation problems?, posted by poser938 on January 12, 2013, at 13:14:45
> I think it could be because there is less serotonin available.
Over time certain people that are sensitive to this effect, SSRI's and other reuptake inhibitors, direct agonists and I believe MAOI's as well stimulate the presynaptic receptors (which act somewhat like a thermostat for neuron synthesis) but as the ssri increases the stimulation, serotonin synthesis and release will decrease. Making less serotonin available for the reuptake.
poster:poser938
thread:1035302
URL: http://www.dr-bob.org/babble/20130112/msgs/1035310.html