Posted by SLS on September 20, 2012, at 10:25:48
In reply to Re: i never tried any TYPICAL ANTI PSYCHOTIC!!! » SLS, posted by phidippus on September 20, 2012, at 9:19:13
Isn't it funny how with modern technology and new data, old drugs can seem new again?
The Ki values for 5-HT1a and 5-HT7 receptors represent fairly low potency. My guess is that these effects do not contribute to the therapeutics of Haldol, especially at the dosages used. However, the potent inverse agonism of D3 receptors comes as a surprise to me. Perhaps this contributes to its efficacy to treat positive symptoms. I wonder, though, if it also is responsible for the depression that you describe.
- Scott
> Firstly, Haloperidol's neglible affinity for histamine H1 receptors and muscarinic M1 acetylcholine receptors yeilds an antipsychotic with a lower incidence of sedation, weight gain and orthostatic hypotension
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> Its a 5HT1A Agonist (Ki 1927nM), a 5HT7 antagonist (Ki 377.2nM)and Dopamine D3 inverse agonist (0.74nM). All of which should help with both negative and positive symptoms of schizophrenia.
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> It also seems to have a wide variety of applications and seems more flexible than a lot of other antipsychotics.
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> Haloperidol is also considered indispensable for treating psychiatric emergency situations-it seems offered in every ER.
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> Drawbacks include Depression, severe enough to result in suicide, is quite often seen during long-term treatment. Also the incidence of extra pyramidal symptoms is on the high side
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> Eric
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Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1026045
URL: http://www.dr-bob.org/babble/20120912/msgs/1026230.html