Posted by SLS on August 14, 2012, at 17:30:30
In reply to Re: Starting minocycline., posted by bleauberry on August 14, 2012, at 16:06:32
Thank you VERY much!
What was it about minocycline that you found difficult to tolerate?
Good old Herxheimer. My doctor and I discussed this.
A friend of mine is also trying minocycline for depression. It produced remission for the first two weeks. In the third week, this person has experienced chronic yawning and somnolence, although the remission remains intact. During the first two days of treatment, he/she felt uncomfortably overstimulated - "wired". Upon dosage reduction, this state dissipated. The depression remitted a few days later, although dosing might still need to be tweaked.
What do you make of the yawning and somnolence that emerged two weeks into treatment? I did not think that these were manifestations of a Herxheimer reaction because the depression did not worsen. I am wrong to have made this assumption. Some of the symptoms do overlap with the Herxheimer reaction. I have reason to believe that something else is going on neurobiologically, but I will consider Herxheimer as a possible explanation, and relay to this person your excellent insights.
FYI, many of the properties of minocycline that I listed are not found with doxycycline or tetracycline. I'll see if I can find a citation for this. I'm sure you recall that I tried doxycycline for a few months without success. I feel that minocycline is different enough from doxycycline to warrant a trial.
Thanks again.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1023257
URL: http://www.dr-bob.org/babble/20120803/msgs/1023282.html