> After 3+ yrs on Marplan and with litle success, looks like im going back to Nardil. Tho I'm trying one last go- despite being on Seroquel before, i was on other stuff too (Valdoxan, Trimipramine, bupropion, clonazepam, Abilify, Solian all within a year and in various combos). Now I've restarted Seroquel with just the Marplan, clonazepam and the bupropion. I figure it best to keep the bupropion as it is one AD to be proven to successfully be augmented by Seroquel.
> Surprisingly I feel better from just a small 25mg afternoon dose followed by a short sleep.
> Soz for the mix in Brands & generics!
> Wish me luck,
>
> Ex
I have personally witnessed a young woman experience an immediate and robust antidepressant effect after taking just one 50 mg dose of Seroquel. She felt great and functioned much better within three days of continued treatment. She was taking Wellbutrin and risperidone at the time. Once risperidone was discontinued and replaced by Abilify, the dosage of Seroquel needed to be brought up as high as 800 mg/day in order to control her symptoms. My guess is that Abilify outcompetes Seroquel for dopamine receptor binding sites on the postsynaptic membrane and thereby inhibits through partial agonism the antipsychotic actions of Seroquel.
- Scott
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