Posted by SLS on August 3, 2012, at 6:24:07
In reply to i wish it was more of a topic... (nm), posted by b2chica on August 2, 2012, at 12:41:19
Mirapex was a hot topic on Psycho-Babble many years ago. You don't see many people post about it anymore. My guess is that the drug is not very helpful when treating depression in general. Bipolar depression? I don't know for sure, but I don't see people claiming a robust antidepressant response to Mirapex.
I once added bromocriptine (a DA D2 receptor agonist) to a combination of MAOI and TCA. I felt very slightly better for a few days - then nothing.
I am leery about using full DA agonists. I don't like the idea of downregulating postsynaptic receptors, and sleep-attacks can be a major side effect. I prefer the persistent improvement that I receive from Abilify. It is a partial agonist, and doesn't seem to have the the pitfalls of using a full agonist. Abilify is sometimes called a "dopamine system stabilizer". It produces a balance between agonism with antagonism based upon the concentration of dopamine in the synaptic cleft.
If I were you, I would choose whichever drug you are most enthused about. If it doesn't help, you might opt to try the other.
Good luck.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1022592
URL: http://www.dr-bob.org/babble/20120803/msgs/1022658.html