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Re: Anyone had success with Savella for depression?

Posted by bleauberry on July 10, 2011, at 19:35:39

In reply to Anyone had success with Savella for depression?, posted by Roslynn on July 9, 2011, at 14:11:56

I like savella. After failing so many meds and then failing ECT, savella actually helped! It did what ECT couldn't.

I had a side effect of urinary restriction which was quite troubling and potentially dangerous, so I had to stop. Other than that a decrease in appetite was about the only other major side effect. Stimulating the first few days and nights, but then really good sleep and more energy during the day.

A few other people here have tried it but didn't have the same effect as me.

It is my belief savella is dosed to high. I was only taking only 25mg....divided into 3 equal doses spread out. I just emptied the powder of capsules and divided it into 3 roughly equal piles and then reloaded each pile in an empty gel cap.

I think people can accidentally be pushed into not giving the drug a chance by having too high of a dose too fast, and then bailing out because of problems. Savella hits norepinephrine pretty hard, and I think the downstream circuits take more time to adapt than serotonin downstream circuits. Probably because they are intertwined with the endocrine system.

Anyway, I am a fan of savella if managed properly. The only other things I might rule out before going to a maoi would be zoloft+nortriptyline; clomipramine; or some creative usage of prozac, zyprexa, ritalin.

> Hi, my pdoc wants me to try Savella, I guess as a last-ditch effort before I would go to the MAOIs.
>
> Does anyone here still take Savella alone or in combo? What was your experience with it?
>
> Thank you!
> Roslynn


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poster:bleauberry thread:990636
URL: http://www.dr-bob.org/babble/20110630/msgs/990711.html