Posted by desolationrower on June 29, 2011, at 0:03:39
In reply to Re: Nardil + cholinergic agent anyone? » desolationrower, posted by SLS on June 28, 2011, at 5:20:01
> It is my understanding that certain nicotinic receptor antagonists, mecamylamine (Inversine) for example, can precipitate or exacerbate depression. Muscarinic antagonists, by comparison, can exert antidepressant effects. If biperiden (Akineton) is still available, that would be my choice of anti-muscarinic.
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> Maybe d/r can check me on this.
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> - Scottall of that sounds right (i haven't heard of biperiden)
nicotine looks like an AD in animal tests, though i think there is some idea that (something?) alpha7? nicotinic receptor downregulation is important, and an antagonist would work too, similar to the 5ht2 role vis-a-vis ssris.
the only drug i have personal experience with is nicotine. the lozenges work almost as well as AMP for adhd for me.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:989447
URL: http://www.dr-bob.org/babble/20110619/msgs/989736.html