Posted by Franz on March 25, 2011, at 12:27:28
In reply to Re: Agomelatine and Tranylcypromine for OCD, posted by linkadge on March 13, 2011, at 17:53:38
> A 5-ht2c antagonist could theoretically increase OCD like behavior. Although fluoxetine is a 5-ht2c antagonist, it is also a SSRI. In other words, the net effect is 5-h5t2c agonism (I believe). Most SSRIs are 5-ht2c agonists, and there are case reports of drugs like cyproheptadine (combined 5-ht2a/c antagonists) causing relapse in OCD patients on SSRIs. Also, there are reports of 5-ht2a/c agonists like tryptamine, mescaline etc. rapidly improving OCD symptoms.
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> Another (theoretical) possiblility is potentiation of 5-ht1a mediated neurotransmission and possible serotonin syndrome. If you haven't experienced this yet, the risk seems low. However, since certain sertonergic antagonists (like antipsychotics) can increase 5-ht1a mediated effects when combined with SSRIs, the risk with combination with agomelatine is a possbililty.
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> You might find that simply taking periodic breaks from the agomelatine (or reducing the dose) is sufficent to regain the anti-ocd effect.
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> LinkadgeI am confused. Why use agomelatine (which I am trying with some problems like short sleep, nightmares, etc.) if fluoxetine is also a 5-ht2c antagonist?. Is it because of the side effects?
Fluoxetine looks like escitalopram+agomelatine and much cheaper. Why are we taking newer and expensive drugs?.
Thanks
poster:Franz
thread:980414
URL: http://www.dr-bob.org/babble/20110321/msgs/981106.html