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Re: venlafaxine to clonazepam » linkadge

Posted by SLS on November 14, 2010, at 10:02:54

In reply to Re: venlafaxine to clonazepam » ed_uk2010, posted by linkadge on November 14, 2010, at 7:53:07

> >Are you going to stick to short term or PRN use >Link?
>
> I am going to first give that a try (i.e. as needed).
>
> However, my doctor actually wants me to take it on a daily basis for ongoing GAD. He seems to think that in certain cases, clonazepam (in particular) can be effective as a maintainance for ongoing GAD.
>
> I'm starting with 0.25mg
>
> Linkadge

Use clonazepam as a tool in the best way you can. Be cognisant, though, that it has the potential to produce a mild to moderate depression as an untoward side effect. It doesn't do this for everyone, but it did affect me that way. The thing I'm not sure of is whether or not the depression resolves with continued treatment. I don't think it does.

Clonazepam is somewhat atypical as a benzodiazepine. It is supposed to be the most effective BZD for controlling seizure disorders. My guess is that lorazepam is better in an emergency, though, as it is faster-acting and has a shorter half-life. Clonazepam is unique for its effects on serotonergic neurotransmission. It is generally thought to enhance serotonin activity. However, some literature indicates that clonazepam reduces serotonin turnover. Unfortunately, it is still unclear as to how it works.

I think it would be worth your time investigating further the pharmacology of clonazepam. There is still much debate as to its mechanisms of action. Perhaps you can uncover what's going on here.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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