Posted by sukarno on November 10, 2010, at 7:30:21
In reply to Re: Stablon update » Conundrum, posted by sukarno on November 8, 2010, at 12:43:23
http://www.mdpi.com/1424-8247/3/10/3143/pdf
Pharmaceuticals 2010, 3, 3143-3166; doi:10.3390/ph3103143
pharmaceuticals
ISSN 1424-8247
www.mdpi.com/journal/pharmaceuticals
Review
Beneficial Effects of Tianeptine on Hippocampus-Dependent
Long-Term Memory and Stress-Induced Alterations of Brain
Structure and Function
Phillip R. Zoladz 1, Carmen Muñoz 2 and David M. Diamond 3,4,5,*
1 Department of Psychology & Sociology, Ohio Northern University, Ada, OH 43222 USA
2 Servier International, 35 rue de Verdun, 92284 Suresnes, France
3 Research & Development Service, James A. Haley VA Hospital, Tampa, FL 33612, USA
4 Department of Psychology, Cognitive and Neural Sciences Division, University of South Florida,
Tampa, FL 33612, USA
5 Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL
33612, USA
* Author to whom correspondence should be addressed; E-Mail: ddiamond@mail.usf.edu;
Tel.: 813-974-0480; Fax: 813-974-4617.
Received: 19 July 2010; in revised form: 26 August 2010 / Accepted: 31 August 2010 /
Published: 11 October 2010===
Excellent, comprehensive article about tianeptine.
I propose that tianeptine causes headaches in the beginning of treatment because it stimulates adenosine-1 receptors. This would cause vasodilation and is the reason behind the headache caused by acute caffeine withdrawal (caffeine is an adenosine receptor antagonist/blocker).
I feel more activating effects today although the antidepressant effect is slow in expressing itself. I seem to have lost my previous tolerance. It is almost like it is 2005 and I'm trying tianeptine all over again.
I've only been on it a few days, so I think in a few more days I will feel better.
I already sleep better (8 to 10 hours a day) and wake up feeling less dread and far less anxiety. I was surprised I could give up diazepam abruptly without any additional anxiety. I also cut back on my caffeine consumption by 50% so this could account for the stress relief too.
I can breathe a lot better (I'm asthmatic). Tianeptine piles serotonin onto platelets, the opposite action of SSRIs in this mode of action. For some reason this helps asthma because the severity of asthma attacks is correlated with higher levels of free plasma serotonin.
I do feel warm in the forehead and eyelids in the morning...almost like a low grade fever but this disappears within 30 minutes of taking a Stablon tablet. This also happened sporadically when I took Stablon regularly for 5 years. I think it might be that its short half-life results in it wearing off somewhat in the morning and then dopamine takes a nose dive. Low dopamine can raise body temperature and abruptly discontinuing dopamine boosting drugs can result rarely in neuroleptic malignant syndrome or fever.
It could also be because Stablon affects the hypothalamus which regulates body temperature. I feel cooler after taking a Stablon.
Paul
alprazolam 1mg QID, tianeptine 6.25mg QID
black tea: 1 cup/day
GNC Ultra Mega Gold vitamin supplement, BIDDx: panic disorder, major depression, probable PTSD
poster:sukarno
thread:967506
URL: http://www.dr-bob.org/babble/20101107/msgs/969553.html