Posted by linkadge on October 2, 2010, at 8:31:07
In reply to Re: Experiment of own on SSRI's » bleauberry, posted by bulldog2 on October 2, 2010, at 7:50:42
>I think we have to take into consideration what >we hear in this forum and what is happening in >the general public.
I partially agree with you, but:
A lot of people are prescribed SSRIs for mild - moderate depression by GPs. This type of depression tends to get better on its own, and is more sensitive to the placebo effect.
The indcidence of side effects (i.e. sexual dysfunction) was grosly underestimated by drug companies. Package inserst say/said ~13% had sexual dysfunction. New questionaires and trials suggest that 60%+ have sexual dysfunction. This calls into question the estimates of efficacy too.
Pooling all clinical trial data (including unpublished trials) suggests that SSRI's are only very marginally better than placebos. These groups were not treatment-resistant. So, unless new, real-world data comes to refute this, this is the only large scale data we have. Catie was not placebo controlled.
I guess what I am saying is that I don't like to assume. Sure, you can assume that psychobabble is not representitive, and that those in the real world do better on SSRI's but what data do we have to support this? Yes, I know people who have got better on SSRI's too, but would they have had an equal response to a placebo?
Linkadge
poster:linkadge
thread:964395
URL: http://www.dr-bob.org/babble/20100926/msgs/964469.html