Posted by linkadge on September 10, 2010, at 10:42:41
In reply to Re: Another semi failed trial » linkadge, posted by Conundrum on September 10, 2010, at 7:59:33
>So basically it is like you said a newer drug >but not as good as older drugs. The dirtier the >drug the better the response right?
Well I don't know if dirty directly equates to efficacy. I just think that there are fads in psychiatry. Sure, some will respond to abilify augmentation just as some respond to lithium augmentation or thyroid augmentation or nortriptyline augmentation. The key idea is that there is money to be made off of abilify at the moment.
The big thing 10 years ago was risperdal / olanzapine augmentation. There were all sorts of fancy studies demonstrating superior efficacy of SSRI + atypical. Overall attitudes have changed towards atypicals however, since the demonstration (in CATIE) that the atypicals are really not more effective than the typicals (in positive or negative symptoms) and that they have more metabolic side effects.
Can't you remember 10 years back everybody being on paxil + zyprexa.
I would think that perphenazine augmentation would be as effective as abilify augmentation. But significantly more doctors use abilify because it is the drug du jour.
Linkadge
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thread:961768
URL: http://www.dr-bob.org/babble/20100908/msgs/961922.html