Posted by rovers95 on July 14, 2010, at 17:40:14
In reply to Re: anti-cholinergic AD's = therapeautic efficacy, posted by SLS on July 14, 2010, at 12:57:27
> > Do the anti-cholinergic side effects of drugs (particulary tricyclics) contribute to their efficacy?
>
> > I found a paper suggesting they did (but know i cant find it!!), but do these effects dissipate with time?
>
> Look for papers involving scopolamine and depression.
>
>
> - ScottI tried scopolamine, it worked but it was weird and withdrawal messed me up.
What i've wondered is whether the long term AD efficacy of tricyclics (and maybe other AD's) could be partly attributed to anti-cholinergic effects (as opposed to just increased moanamine's....which in turn could also create a predominance over acetylcholine).
thanks
rover
poster:rovers95
thread:954464
URL: http://www.dr-bob.org/babble/20100709/msgs/954495.html