Posted by bleauberry on February 17, 2010, at 17:50:30
In reply to SSRI/SNRI ratio: Citalopram/Nortrip vs. Savella, posted by Bob on February 17, 2010, at 14:19:39
Rather than shooting for a predetermined ratio, the appropriate dose would be the one that "feels" right to you. Which would take some experimenting.
There really is no direct comparison anyway, because Nort is doing a lot of other stuff besides NE, some of which may be therapeutic and some not, we don't know. Savella, same thing, there is more going on at a molecular level than we currently know. Even with old meds like Nort, there is so much we don't know. Much more research is needed.
The right ratio is the one that feels best to you. That might be 1:3, 2:5, 7:2, who knows.
Based on my own experimenting with Nort and Zoloft, it felt to me like 12:5mg Zoloft and 20mg Nort were about equal. That said, no dose of any size felt like it had the direct yet clean emphasis on NE. Even a tiny dose of Savella had a pleasant ummph on NE with a soft touch of 5ht. Whereas Nort did not feel potent or clean, and Zoloft felt like it was messing with something else unwanted besides just serotonin.
But that's just me.
poster:bleauberry
thread:937250
URL: http://www.dr-bob.org/babble/20100216/msgs/937262.html