Posted by linkadge on January 31, 2010, at 11:56:02
In reply to Re: Best Antidepressant For Pain?, posted by bulldog2 on January 30, 2010, at 22:20:31
I don't know if tramadol is "addictive". Its not technically a pure opiate. It does interact a little with opiate receptors (as does effexor and the TCA's to a lesser extent), but pain modulating effects are also due to interaction with serotonin/norepinephrine reuptake.
The norepinephrine transport has some effects on the duration of opiate analgesia. NRI's have pain killing effects in their own right. SSRI's, to a lesser extent, can also modulate pain perception.
I wouldn't say that tramadol is any more addictive than effexor. I know some people who use it long term for depression.
Linkadge
poster:linkadge
thread:935416
URL: http://www.dr-bob.org/babble/20100122/msgs/935502.html