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Re: Litium is neuroprotective? You sure? Breggin? » linkadge

Posted by SLS on November 11, 2009, at 15:40:58

In reply to Re: Litium is neuroprotective? You sure? Breggin?, posted by linkadge on November 11, 2009, at 15:30:47

> I'm not exactly sure of the association. If GSK-3b gets too high then (as SLS mentioned) there can be cell death. If GSK-3b gets too low there is also a reduction in some forms of placticity. GSK-3b is important for triggering axonal growth in the early stages of developement. GSK-3b inhibition is supposedly partially responsible for the tetarogenic effects of lithium and divalproex.
>
> I also know that mild gsk-3b inhibition improves neurotransmission but if gsk-3b inhibition gets too low there are significant derangements in normal brain function (ie sensorimotory gating deficicts, latent inhibition issues). I think some studies have found that gsk-3b is dramatically reduced in schizophrenia.


The depth and scope of your knowledge always astounds me - even when we are angry with each other.

:-)

I wish I had your memory for detail. Maybe someday...


- Scott

 

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