Posted by SLS on November 11, 2009, at 15:40:58
In reply to Re: Litium is neuroprotective? You sure? Breggin?, posted by linkadge on November 11, 2009, at 15:30:47
> I'm not exactly sure of the association. If GSK-3b gets too high then (as SLS mentioned) there can be cell death. If GSK-3b gets too low there is also a reduction in some forms of placticity. GSK-3b is important for triggering axonal growth in the early stages of developement. GSK-3b inhibition is supposedly partially responsible for the tetarogenic effects of lithium and divalproex.
>
> I also know that mild gsk-3b inhibition improves neurotransmission but if gsk-3b inhibition gets too low there are significant derangements in normal brain function (ie sensorimotory gating deficicts, latent inhibition issues). I think some studies have found that gsk-3b is dramatically reduced in schizophrenia.
The depth and scope of your knowledge always astounds me - even when we are angry with each other.:-)
I wish I had your memory for detail. Maybe someday...
- Scott
poster:SLS
thread:925110
URL: http://www.dr-bob.org/babble/20091107/msgs/925386.html