Posted by Sunbath on October 4, 2009, at 16:53:05
In reply to cleanest TCA for sleep, after nortrip?, posted by g_g_g_unit on October 4, 2009, at 9:19:53
Hi g_g_g!
I think it's a great decision not to ditch parnate already!!
The only thing I'd like to tell you is that you need to try it out all yourself!
Theoretical doxepine is nice, because you can take really low doses of it, without much or any anticholinergic activity, because it's such a strong antihistaminergic drug. BUT also it could be very well that you don't like it. For me it's sedating me too much during the day, even in very low doses...
Maybe amitriptyline would feel better, maybe trimipramine would.. But also keep in mind that trimipramine's also a somewhat dirty drug because it's a moderate d2 antagonist and relatively strong anticholinergic.
Also I personally (might be wrong of course) don't think that it has much sense to go for a sleep aid only because it doesn't suppress rem sleep, when you are already taking a drug which almost completely abolishes rem sleep.. Parnate is doing that by a GREAT deal on its own!Also, as far as I understand it, trimipramine isn't known for its very strong antidepressant properties, but for example amitriptyline is. Maybe your sleep aid could also be a synergistic medication for parnate as Scott is telling us could be very important? But of course maybe you'd like something else better.. it's really hard and strange that everyone's so different..
Good luck!! I'm sure you will find something that's working well for you!
poster:Sunbath
thread:919653
URL: http://www.dr-bob.org/babble/20091001/msgs/919705.html