Posted by number42 on October 1, 2009, at 11:09:57
In reply to Re: How does Abilify augment antidepressants?, posted by SLS on September 30, 2009, at 14:50:58
> > I recently added Abilify 20 mgs. to 80 mgs. of Prozac and i am doing so much better. Anyone familiar with how an anti-psychotic enhances an AD?
>
> With Abilify, there are probably at least three mechanisms involved:
>
> 1. Dopamine D2 and D3 receptor partial agonism.
>
> 2. Serotonin 5-HT2a receptor antagonism.
>
> 3. Serotonin 5-HT1a receptor partial agonism.
>
> The net effect here is to increase dopamine and serotonin activity.
>
> Linkadge could probably add some insight into what are the downstream effects of these events.
>
>
> - ScottThanks Scott.
poster:number42
thread:919132
URL: http://www.dr-bob.org/babble/20091001/msgs/919263.html