Posted by linkadge on September 15, 2009, at 16:53:12
In reply to Re: stim/NRI - also, NRI time delay, posted by TenMan on September 13, 2009, at 12:41:47
>Wouldn't reduced DAT be an adaptive response to >low levels of circulating DA?
Yes, which begs the question of how a DAT inhibitor would really do anything at all. Surely if the brain can reduce DAT, it would do so to the extent that dopamine receptor signalling becomes optimal with the given amount of dopamine.
>I remember reading one study on amphetamine >which showed an increase in DAT after chronic >administration. The reduced number of receptors >puzzles me however. I would think it would be >the opposite but perhaps that is just part of >the dysfunctional system?
Yeah, and there was a fairly recent study that suggested the way that methylphenidate operates in the disease model of ADHD is entirely different from that in normal orgnaisms. In one disease model for ADHD, dopamine release patterns are all wacky - and methylphendiate almost acted like a dopamine system stabilizer - preventing surges in dopamine release.
Linkadge
poster:linkadge
thread:916581
URL: http://www.dr-bob.org/babble/20090912/msgs/917257.html