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Re: Amitriptyline directly stimulates NGF receptors

Posted by Brainbeard on June 28, 2009, at 8:27:07

In reply to Amitriptyline directly stimulates NGF receptors, posted by Darwin on June 26, 2009, at 15:37:33

>
>
> "The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown."
>
> Here's the complete article:
>
> http://www.physorg.com/news165152571.html

Very interesting. My next question would be: is this effect dose-related? Amitriptyline can mitigate pain at low dosages (in the range of even 5 to 50mg). If its analgetic qualities are related to the phenomenon discussed, amitriptyline might exert these brain repairing(/enhancing?) actions even at low doses.

I've just received a bunch of amitriptyline and have just started using it low dose. I take it for chronic pain and for its anxiolytic 5HT2A-antagonism, which may also counter SSRI-induced apathy related to decreased noradrenaline firing if I understand this abstract correctly: http://www.journals.elsevierhealth.com/periodicals/bps/article/PIIS0006322306006597/abstract.

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Current meds: imipramine 12.5mg, sertraline 12.5mg, amitriptyline 6mg, ondansetron 2mg several times a day, modafinil 50mg
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poster:Brainbeard thread:903326
URL: http://www.dr-bob.org/babble/20090620/msgs/903581.html