Posted by g_g_g_unit on June 23, 2009, at 0:37:49
In reply to Re: How long is a fair trial? (Memantine) » g_g_g_unit, posted by Kimbersaur on June 22, 2009, at 19:12:59
to be honest, i don't have a great understanding of the science behind it, but i'll give it a shot. so @ 20mg, a person with a normal drug metabolism would be excreting enough of the drug so that that 20mg would stay at a relatively constant level in their blood on a day-to-day basis, at least after you've been on a given dose for about a week - in other words, they could be assured that they're taking 20mg. but what if you were removing less of the drug from your body because your urine has an abnormal pH? then, because it has such a long half-life, it would begin to accumulate, meaning you could be taking 20mg, but in effect be 'overdosing' (not in a dangerous sense), but just be taking more than you think you are because its not being excreted from your body at a consistent rate. i wouldn't worry about it too much, but it just means that you could have missed your optimal dose. i'm withdrawing from the drug at the moment, but staying at each dose on the way down for about a week just to make sure. so far 15mg still isn't improving things much, but i might see what 10mg is like. if that doesn't work out, i'll ditch it.
poster:g_g_g_unit
thread:902381
URL: http://www.dr-bob.org/babble/20090620/msgs/902701.html