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Re: Serious issue to me » SLS

Posted by desolationrower on April 15, 2009, at 1:55:32

In reply to Re: Serious issue to me » desolationrower, posted by SLS on April 14, 2009, at 15:40:02

> > scott why do you think i i don't notice stimulant effect from parnate or get insomnia
>
> Either you have been desensitized from previous drug exposures, or perhaps you are not yet at your therapeutic dosage. A third possibility is that you have been in a hypernoradrenergic state (or perhaps a hypercortisolemic state) for so long, that your postsynaptic NE receptors have downregulated, leaving you with a diminished acute stimulatory response, but not necessarily an impediment to future antidepressant response.
>
> The very first time I tried Parnate in 1982, I did not experience insomnia. It was only when desipramine was added that I suffered total insomnia. It was also that combination that brought me to full remission for many months. If my doctor at the time hadn't been so "smart", I would never have remained depressed for the last 22 years... Long explanation.
>
>
> - Scott
>
>
>

thanks scott. any time you want to speculate on me more i'll be grateful. i guess my thought was the adhdi gives such low catecholaminergic tone in the pfc that a weaker stim like parnate never really gets past the stage of alpha2/d1 receptors. it seems odd it wasn't a therapeutic dose, since it works so well for depression. i think there is a lot of COMT in the pfc.

-d/r

 

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