Posted by psychobot5000 on January 22, 2009, at 14:53:54
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl, posted by linkadge on December 22, 2008, at 14:05:59
For those few who might be interested in 5ht(2c) and its effects on OCD, here's a brief account of 5ht(2c) antagonist Agomelatine's effects on my symptoms thus far...
I has had dramatic effects. And yet, I am not entirely certain I would recommend it to someone else. The ruminative components of my OCD are gone or severely reduced. Concerns with things like, say, handwashing, are more or less gone. However, a certain -feeling of obsessive urgency- has arisen or been magnified, and it's connected to a certain physical obsessiveness...repetitive and unnecessary movements, like winking (not at someone--just on my own). Thinking back, this reaction is somewhat similar to my reaction to Remeron, though more dramatic. It's probably less unpleasant than the previous incarnation of my OCD, but it's always present, and disrupts my ability to work without distraction.
Problematic. I have no idea what it means in neurobiological terms, but I thought I'd throw it out there, for those with an interest in this stuff: ruminative symptoms largely eliminated, physical obsessiveness much increased. Patient claims subjective similarity to previous experience with Remeron.
(incidentally, I more recently added low-dose nefazodone to my regimen, but I attribute most of the change to Agomelatine, as it started before the second drug was added)
Psychbot
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20090104/msgs/875462.html