Posted by karl on December 19, 2008, at 17:40:03
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by karl on December 19, 2008, at 15:15:07
"when first-pass metabolism is circumvented, the maximum plasma concentration of selegiline is increased 60-fold and the balance of metabolites is altered significantly, halving the production of amphetamines..."
http://apple2.org.za/gswv/me/selegiline.structure.pdf
i'm going to stop pretending now that i have anything valuable to say about selegiline's metabolites.
but i'll stand by my point that people who take selegiline need to try to understand the different feelings they get from the two different actions of the drug, 1) metabolites and 2) mao-b inhibition. if it's the metabolites that are making them feel better, they should know that one can buy levo-methamphetamine at the drug store and that they may not need to order selegiline from overseas or pay $600/month for emsam patches. it's called levmetamfetamine now [to try to discourage abuse] and they put it in Vicks Inhalers, although according to wikipedia it's soaked in cotton and combined with menthol and camphor, so dosing is obviously tricky if not impossible. i don't know where one could obtain pure levmetamfetamine. if you know, kindly post a follow-up.
either way, if you feel like trying some mao-b inhibition on its own, you don't need much selegiline and you don't have to take it very often.
"MAO-B is irreversibly inhibited by 90% within 30-90 minutes, and remains so until it can be re-synthesized by the body -- a period of up to 40 days."
http://apple2.org.za/gswv/me/selegiline.structure.pdf
"...by 96 hours (four doses) the inhibition of platelet MAO-B activity is approximately 95% after a daily dose of 2.5 mg selegiline, whereas it takes only 48 hours (two doses) for doses of 5 mg and 7.5 mg to achieve this degree of inhibition."
in fact, i think i'll post this on its own for anyone searching for information on selegiline.
poster:karl
thread:825078
URL: http://www.dr-bob.org/babble/20081214/msgs/869695.html