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Re: Low dose naltrexone - comments please

Posted by Phillipa on October 18, 2008, at 12:47:42

In reply to Re: Low dose naltrexone - comments please » uncouth, posted by Phillipa on October 18, 2008, at 12:22:40

A little one with bipolar mentioned. Phillipa


Funded by:
Stanley Medical Research Institute Bipolar Disorder Center at UT Southwestern Medical Center

Keywords
mood disorders substance dependence depression mania opioid receptor


Abstract
Bipolar disorder is associated with very high rates of substance abuse. However, few clinical trials are reported in this population. Naltrexone is effective for alcohol dependence, but its safety and efficacy are not established in patients with bipolar disorder and alcohol dependence. A 16-week, open-label, add-on pilot study of naltrexone was conducted in 34 outpatients with bipolar disorder and alcohol dependence. Assessments included the 17-item Hamilton Rating Scale for Depression (HRSD-17), Young Mania Rating Scale (YMRS), Brief Psychiatric Rating Scale (BPRS), and an alcohol craving scale. Alcohol use was quantified. Significant improvement was observed in the HRSD-17 and YMRS, and days of alcohol use and craving decreased significantly. Naltrexone was well tolerated. Controlled trials are warranted. Depression and Anxiety

 

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