Posted by SLS on September 1, 2008, at 13:33:59
In reply to Re: Mirapex dosage as add-on antidepressant?, posted by desolationrower on September 1, 2008, at 12:01:05
Hi.
I looked into it and discovered that you are right regarding the relative binding affinities of Mirapex and Abilify being about equal. As far as "threading the needle" is concerned, that is pure conjecture and does not take into consideration any regional differences in the kinetic deposition of drug. It is not only what, but where. I guess that is another thing to investigate to help put this story together.
Your theory makes sense. However, I personally don't rely too much on our theories to make clinical decisions. There is too much at stake. Combining Abilify with Mirapex might yield a positive net result for reasons we don't understand or have access to. The combination is probably safe. We don't even know if Abilify would help prevent the sleep attacks that come with Mirapex. It might, given that the binding affinity of Abilify to presynaptic autoreceptors is greater than that of Mirapex, and that a stabilization of the dopamine synapse may still be stabilized by the partial agonist property of Abilify at D2 postsynaptic receptors.
That's a hastily thought-out theoretical scenario that could also make sense now that a few more facts have been added.
Given that the Abilify + Mirapex combination seems safe, it becomes nothing more than a clinical experiment to be performed on someone who has thus far not found an adequate treatment.
- Scott
poster:SLS
thread:849566
URL: http://www.dr-bob.org/babble/20080822/msgs/849725.html