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Re: Beta Blockers and Depression

Posted by undopaminergic on July 4, 2008, at 12:02:59

In reply to Re: Beta Blockers and Depression » Larry Hoover, posted by KarenRB53 on July 3, 2008, at 21:05:36

>
> Presently I'm taking 150XL Wellbutrin and 20mg Prozac daily. I have Essential Tremor and my internist wants me to take Propranol 80mgXR daily. I'm concerned about taking these meds together and how they'll affect each other. I'd appreciate any information.
>
> Thanks,
> Karen

I'm not aware of any specific interactions, but propranolol is somewhat risky to take if you're depressed. This is because in addition to beta1-adrenoceptors, it also blocks beta2-, and postibly beta3-adrenergic receptors, and that will result in reduced brain uptake of aromatic amino acids, including tryptophan, which is the precursor of serotonin.

Have you tried zonisamide for your essential tremor? Memantine might also he useful.


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