Posted by undopaminergic on June 7, 2008, at 20:19:09
In reply to Re: Any doctors in UK prescribe dexedrine??, posted by West on June 7, 2008, at 13:12:30
> I am intersted in amilsupride which i understand is an asti-psychotic, but at low doses a partial dopamine agonist which sounds very interesting.
>It's not a partial dopamine agonist, but a pure antagonist. The good thing is that it preferentially blocks presynaptic dopamine receptors that function as autoreceptors. Since these autoreceptors reduce or inhibit dopamine release, blocking them with amisulpride results in enhanced dopamine release, and as long as the dose of amisulpride is low enough not to negate the effect of increased neurotransmitter release by too extensive blockade of postsynaptic dopamine receptors, the result is a stimulant effect.
A good cheaper alternative to amisulpride is sulpiride.
> Will it produce a ritalin-style lift and focus?
>Yes, in my experience. Unfortunately, as with Ritalin, tolerance can develop and greatly diminish the effects.
Amisulpride/sulpiride and Ritalin can be used in combination, sometimes resulting in a stronger effect than with either drug alone.
poster:undopaminergic
thread:833341
URL: http://www.dr-bob.org/babble/20080606/msgs/833532.html