Posted by bleauberry on May 9, 2008, at 17:19:31
In reply to Wonder Why Wellbutrin was So Bad - Me too. » bleauberry, posted by SLS on May 9, 2008, at 5:00:41
Hi Scott,
Thanks for your input. I always appreciate hearing your thoughts.
As you said, I believe Wellbutrin is a weak reuptake inhibitor. I saw somewhere at pubmed where 300mg provides 20% occupancy of dopamine reuptake. Consider that zoloft has 90% occupancy of serotonin reuptake at just 25mg, or even 50% at a mere 9mg, wellbutrin is weak compared to peers. I've read other postulated effects of wellbutrin having to do with nitric oxide and nicotinic receptors and who knows what.
This happened with a trial of adding wellbutrin to zoloft about 2 years ago. Enough time has passed that I figured it was a fluke and surely wouldn't happen again. Surely it had something to do with the combination of zoloft, but with wellbutrin by itself it would be different. Wrong. While I see other people get huge benefits from wellbutrin, to me it is like taking rat poison.
As far as norepinephrine reuptake goes, reboxetine made my depression a lot worse and fast, nortriptyline was neutral, and milnacipran had me feeling better than in a long time within a week. Go figure. It just seems a lot more complicated than saying norepinephrine reuptake is bad for me or is good for me. I think it depends on what drug is doing it, how it is doing it, and where in the brain it is doing it. as well as other intricate detailed secondary functions we may or may not know about.
poster:bleauberry
thread:828024
URL: http://www.dr-bob.org/babble/20080430/msgs/828226.html