Posted by undopaminergic on April 25, 2008, at 3:30:04
In reply to SUBOXONE INTERACTIONS?, posted by AnxiousAnnie on April 24, 2008, at 22:07:39
"Deaths have also been reported in association with concomitant administration of buprenorphine with other depressants such as alcohol or other opioids."
"Buprenorphine is metabolized to norbuprenorphine by cytochrome CYP 3A4. Because CYP 3A4 inhibitors may increase plasma concentrations of buprenorphine, patients already on CYP 3A4 inhibitors such as azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), and HIV protease inhibitors (e.g., ritonavir, indinavir and saquinavir) should have their dose of SUBUTEX or SUBOXONE adjusted."
"Patients should be cautioned that a serious overdose and death may occur if benzodiazepines, sedatives, tranquilizers, antidepressants, or alcohol are taken at the same time as SUBOXONE or SUBUTEX."
poster:undopaminergic
thread:825297
URL: http://www.dr-bob.org/babble/20080420/msgs/825337.html