Posted by undopaminergic on April 11, 2008, at 18:06:04
In reply to Re: Lexapro-)dilated pupils--)look like I'm on 'dr, posted by llurpsienoodle on April 11, 2008, at 17:11:32
> last year I asked my then-pdoc about the dilated pupils I had while on cymbalta- he said that pretty much any drug that affects norepinephrine has a chance of causing the pupil dilation. But serotonin is a new one for me...
>Pupil size regulation is a rather complex matter. Some factors play more direct roles, and others act more indirectly, by affecting other factors. Furthermore, some factors play a local role and others act centrally (via the brain). So, for example, the local effect of adrenaline - as eye-drops - is to dilate the pupil, but some centrally acting adrenergic drugs can constrict the pupil. There are also differences between species, and between individuals.
> I was on zoloft for mos and no dilated pupils, but ever since I started wellbutrin a month ago, my pupils have been bigger.
>My experience is the opposite: methylphenidate does little to my pupils but Zoloft dilates them.
> it used to be a sign of beauty "belladonna"
>
> -LlBelladonna (deadly nightshade), or more precisely, its active principles (atropine and related alkaloids) is an example of a local and direct acting drug, blocking muscarinic acetylcholine receptors. I've confirmed the effects using Brugmansia (Angel's trumpet) - a close relative of the Belladonna. Datura (Thorn-apple or Jimsonweed) should work too.
poster:undopaminergic
thread:822454
URL: http://www.dr-bob.org/babble/20080330/msgs/822750.html