Posted by Dopamine123 on February 21, 2008, at 17:20:24
In reply to Re: Lexapro for 2 weeks... now somethings gone wro, posted by elanorroosevelt on February 16, 2008, at 9:51:41
Anxiety from SSRI's is usually caused by increased activation of specific serotonin receptors. SSRI's increase serotonin in the synapse which activates multiple receptors.
Agonist activation of the 5-HT1A receptor mediates the antidepressant/anti-anxiety effects of the SSRI's, while activation of 5-HT2A, 5-HT2C, 5-HT3 and several others, mediate the side effects (such as increased anxiety, insomnia).
Seroquel blocks the 5-HT2A receptor and decreases serotonins effect there, which is good for anxiety/sleep. However It isn't an antagonist at other serotonin receptors.
Risperidone is an antagonist at serotonin 5-HT2A receptors and 5-HT2C receptors.
Remeron antagonizes the 5-HT2A, 5-HT2C, and 5-HT3 receptors.
Ziprasidone is an antagonist at serotonin 5-HT2A, 5-HT2C receptors while being an agonist at 5-HT1A receptors.
So you might want to try a different drug that gives you antagonistic action (decreasing serotonin effects) at 5-HT2A, 5-HT2C and 5-HT3 receptors while being agonist (increasing serotonins effect) at 5-HT1a receptors. That should give the best antidepressant/anti-anxiety effect.
Hopes that's not too technical.
My neuroscience/neurotechnology blog:
http://brainstimulant.blogspot.com
poster:Dopamine123
thread:812520
URL: http://www.dr-bob.org/babble/20080221/msgs/813963.html