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Re: Puzzled- sertraline making things better or wo » CareBear04

Posted by rgb on February 2, 2008, at 13:14:08

In reply to Re: Puzzled- sertraline making things better or wo » rgb, posted by CareBear04 on February 2, 2008, at 11:23:13

@Phillipa: I'm going to stick with it for now since it /does/ have an effect, just with some downsides.

@CareBear04:

> what you were describing seemed to make more sense before you mentioned that you're been on zoloft for nine months. for some reason, i seem to be sensitive to SSRIs, especially when starting them, and i have all the effects you described. my mood is better with all the improvements that accompany that, but i feel very restless, both physically and mentally. i can still think conceptually but have a hard time organizing and focusing my thoughts for an immediate task at hand. when i've taken SSRIs without a mood stabilizer, i've become manic.

Interesting that you had the same reaction. By the way, how did the issue from the other thread work out for you, did you go back on an antidepressant?

> that said, it's curious as to why you're experiencing these effects now after nine months. have you maybe had them for a long time now and are just now noticing them? have you increased your dose or otherwise changed your meds? most people who have akathisia/over activation-type reactions have them at the start, and they either discontinue or the side effects decrease over time.

Yes, it didn't begin suddenly and I think I've mostly become more aware of it. My dose has been 200mg for some months.

I did recently switch to a different generic which appears a bit stronger. The wikipedia says that the allowed bioavailability ratio to the original is 80-125% (where I live), which would be a sizeable 1.56-fold difference between the extreme ends.

The occasional serotonergic euphoria was there right from the beginning. Not sure whether the restlessness was there from the start as well.

I know some symptoms resemble minor mania but I like the smiling-a-lot parts and don't really want to start a mood stabilizer (I think I have no bipolar tendencies without drugs).


> on balance, do you feel that the zoloft is helping? do the benefits outweigh the restlessness?

I really don't know. I should continue it for now and see whether the restlessness decreases with more social and/or productive activities (easier said than done).

> good luck,
> cb

Thanks =) Good luck to you too!


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