Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Bummed! Depakote caused liver enzymes to rise! » AnneL

Posted by kaleidoscope on November 11, 2007, at 13:02:51

In reply to Bummed! Depakote caused liver enzymes to rise!, posted by AnneL on November 10, 2007, at 12:25:26

Hi

Depakote causes raised liver enzymes very frequently, a problem which is normally transient and does not generally represent a serious problem. Of course, Depakote can cause severe liver damage - it's certainly not common though. With Depakote, a prolonged prothrombic time (a blood test) represents liver injury, whereas raised liver enzymes don't really mean that much. Most patients with raised liver enzymes on Depakote are asymptomatic.

Here are the guidelines from the UK.....

Liver toxicity

Liver dysfunction (including fatal hepatic failure) has occurred in association with valproate (especially in children under 3 years and in those with metabolic or degenerative disorders, organic brain disease or severe seizure disorders associated with mental retardation) usually in first 6 months and usually involving multiple antiepileptic therapy. Raised liver enzymes during valproate treatment are usually transient but patients should be reassessed clinically and liver function (including prothrombin time) monitored until return to normal—discontinue if abnormally prolonged prothrombin time (particularly in association with other relevant abnormalities).


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:kaleidoscope thread:794279
URL: http://www.dr-bob.org/babble/20071104/msgs/794398.html