Posted by linkadge on July 24, 2007, at 9:11:09
In reply to Re: SSRI brain damage » linkadge, posted by Larry Hoover on July 24, 2007, at 8:31:50
>during exposure. I don't mean to sound >argumentative, but the issue for me would be >whether the stress reaction rebounded to more >normal parameters after the drug had worn off.Hey, don't worry. I like discussion. There are a few other possable mechanisms. Apparently fluoxetine decreases the reuptake of glutamte. (I think hyperforin does as well). This may be more the mechanism of enhanced toxicity.
>You inadvertently pasted in the same link for >the first paper.Sorry, this is the one I was referring to:
http://psy.psychiatryonline.org/cgi/content/full/42/2/163-a
>The researchers do not report the dose of >sertraline. Moreover, it appears to have been >injected. At best, the concerns are suggestive >for further research. I know of no link between >sertraline and seizure in humans.Most antidepressnats need to be used cautiosly in individuals with epilepsy as many can often worsen the underlying seizure disorder. It is possable that even subseizure kindling like activity may tax neuronal circutry.
>I'm really concerned by certain interpretations >of studies like these. Time-dependent regulatory >changes are not evidence of damage.
Well it depends what one means by regulatory changes. I wouldn't consider, for instance, fluoxetine drop in melatonin levels, a necessary drug mechanism. There are plenty of non depressed people with normal melatonin levels. Lowering melatonin levels can also lower the seizure threshold.
Although there are many possable side effects that could lead to toxicity, I personally believe that negative studies are more influenced by lack of money and publication bias.
I'll be the first to admit that I havn't proven anything.
But I would like to think that I come out ahead in the end :)
Linkadge
poster:linkadge
thread:771164
URL: http://www.dr-bob.org/babble/20070719/msgs/771584.html