Posted by Racer on June 3, 2007, at 14:16:32
In reply to Re: Fluoxetine potentiates bupropion » magicpill, posted by Phillipa on June 3, 2007, at 13:25:08
What that abstract is saying is that Prozac makes Wellbutrin more effective.
In medium words ;-), Prozac potentiates the action of Wellbutrin. When they gave rats Wellbutrin, there were dose dependent increases in dopamine and norepinephrine, but they were pretty mild increases. When they gave the rats Prozac first, though, the increases went up a huge amount. There were three doses given the rats -- 10mg per kg of body weight, 30mg/kg, and 100mg/kg -- and they produced increases of roughly 0%, 240%, and 600% above baseline respectively. The 10mg/kg and 30mg/kg doses, after the rats were pretreated with Prozac, produced increases of 350% and 570% in the hypothalamus. The Prozac pretreatment also affected the release of dopamine in the prefrontal cortex, although not norepinephrine in that area.
What this means, is that Wellbutrin may be more effective at lower doses if given with a low dose of Prozac. Wellbutrin is often not a terribly robust antidepressant on its own, and this suggests that adding a low dose of Prozac might boost its powers.
How's that? Easier words, and medium words. A bonus! And if you have any other questions, ask away...
poster:Racer
thread:761035
URL: http://www.dr-bob.org/babble/20070524/msgs/761049.html