Posted by brooke484 on April 27, 2007, at 14:04:22
In reply to giving up on nardil, posted by jenny80 on April 26, 2007, at 9:36:57
Treatment-Resistant Depression: Strategies for Management
Alicia R. Ruelaz, MD
Despite advances in our understanding of depression therapy, many patients with depression remain unresponsive to treatment. As many as 50% of patients who begin treatment with an antidepressant do not respond.1 In fact, even after 2 antidepressant trials, 30% to 40% of patients do not report significant improvement in their symptoms.2 There is no universally accepted definition of treatment-resistant depression; however, a working definition is depression that fails to respond to an adequate trial of antidepressant treatment. In this case, nonresponse is defined as the failure to obtain at least a 50% reduction in symptom severity on a standard rating scale score. A growing consensus in the field suggests that an adequate trial of an antidepressant is the highest dosage tolerated by a patient within the approved therapeutic range for 6 weeks.I thought the last sentence was important. I remember when I was on Imipramine it took months for me to get to the right dose (400 mgs) and then after that it took a few weeks for it to kick in. You must be patient, hard as it is.
Brooke
poster:brooke484
thread:753590
URL: http://www.dr-bob.org/babble/20070426/msgs/753981.html