Posted by michael on February 20, 2007, at 10:50:15
In reply to Re: Antipsychotics+motivation » Klavot, posted by Quintal on February 17, 2007, at 17:57:04
> Were you referring to Solian (amisulpride) perchance? Amisulpride enhances dopaminergic transmission at doses of 50mg and below by blocking presynaptic autoreceptors (which are a feedback mechanism for controlling dopamine production and release into the synapse). This results in higher dopamine levels in the synapse and hence the pro-motivational effects.
>
> Amisulpride and sulpiride are unique in doing this as far as I'm aware.
>
> Q
Just writing to concur re: amisulpride & sulpride...At low doseages (I believe as mentioned above, amisulpride @ 50 mg and below, and sulpiride @ 50-150 mg) they're used as antidepressants.
I know that at least in Italy, amisulpride was approved by their equivalent of the FDA explicitly for dysthymia (which is a type of depression)
michael
poster:michael
thread:733596
URL: http://www.dr-bob.org/babble/20070219/msgs/734445.html