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PEA with selegiline(Emsam) is dangerous

Posted by danr49 on January 20, 2007, at 16:42:25

I know this technically is supposed to go to the alternative board, but I don't know how many people actually read there. And I know many people are experimenting with this, so I'm posting on this board because it's important:

When you take phenylethylamine (PEA) with an MAOI, there's going to be a pressor dosage where the PEA will start to increase blood pressure and this dosage is likely < 50mg, due to norepinhephrine release just as with tyramine ingestion. After the pressor dosage is reached, even small amounts of increase over this amount will equate to substantial increase in blood pressure.

This can lead to hypertensive crisis that may cause stroke, death, etc.

The studies used carefully controlled dosages of a cap of not more than 20mg at a time given a few times daily.

Just 50mg (maybe less) at once while on an MAOI may cause a significant rise in blood pressure, and once you go much above this you're talking about hypertensive crisis and the possibility of dropping over dead. All it would take is mistakingly measuring out the powder wrong or something.

In other words, I would strongly recommend not doing this.


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poster:danr49 thread:724542
URL: http://www.dr-bob.org/babble/20070119/msgs/724542.html