Posted by blueberry1 on January 15, 2007, at 16:32:01
In reply to Re: it's called pssd, posted by linkadge on January 15, 2007, at 8:57:46
Well, maybe if ssris permanently screw with the serotonin synthesis from tryptophan in a negative profound permanent way, then it would be easy to win that battle with simple 5htp supplements? Just completely bypass the tryptophan conversion thing. With or without an antidepressant, maybe carelful 5htp dosing could do that?
To partially answer my own question though, 5htp did zilch for my anhedonia and actually made my sexual dysfunction far worse than any medication ever did. It did a fair job of masking or numbing out the depression, similar to ssris, with the same blah feeling, serotonin anxiety, and serotonin insomnia. Just the opposite of what 5htp fanatics claim.
Oh well. You are probably right. We are f**cked, at least for a while, until we find the right meds or alternative supplements for ourselves. I have faith it will happen.
> Wow, that Wikipedia article was intense.
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> >But experiments with rodents have shown that >chronic treatment with SSRIs at a young age >results in permanently decreased sexual behavior >that persists into adulthood and is similar to >PSSD[9][10]. At the cerebral molecular level >there are profound and permanent reductions in >both the rate-limiting serotonin synthetic >enzyme, tryptophan hydroxylase, in dorsal raphe >and in serotonin transporter (SERT) expression >in cortex.
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> I'm f*cked. OH well, what can you do?
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> Linkadge
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poster:blueberry1
thread:722168
URL: http://www.dr-bob.org/babble/20070113/msgs/722604.html