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Re: General Maoi Tip-SLS

Posted by tessellated on January 4, 2007, at 15:36:22

In reply to Re: General Maoi Tip » willyee, posted by SLS on January 1, 2007, at 9:07:30

yep, i hate that bitter pill. i only get the parnate "golden mean" after having taken it for fourteen hours. then it turns me into some vampire like superhuman, working all night 36hrs etc...then crashing for 12-14.
makes sleeping with a partner difficult.
i'm a tad fearful of the manic potential insomnia itself has.
so i've switched over to milnacipran, because of it chemical similarity to parnate. its more often compared to cymbalta due to its SNARI profile. damn stuff isn't in the states, but is worth looking into.

Scott,
Not to be blunt, but wow you got a heck of a line up going on there. Layer after layer of anticonvulsants/antipsycho's, i would imagine would give anyone a zombie ride. i think i lost it trying to combine seroquel with parnate, passing out convulsing, etc.

i'm tending to err on the side of minimizing polypharmacy options, because there are no controls, and so many variables, including different rates of receptor adaptation.

i just took a break of about two months from any constant meds to see what my baseline was, and all the paranoia/mania just dissapeared. i almost think i have to give my neurons a break a few months a year or i'd get swallowed up by a well of pills...

obviously you've spent time developing this cocktail, so this is nothing more than a common sense suggestion: reduce variables.

it sounds ridiculous, but realizing my baseline didn't involve paranoia/anxiety/mania, was a HUGE relief. even though i feel like a potatoe-tired etc, it feels like i have a clear picture that i'm not inherently bipolar.

you got a lot of neural inhibition happening in both the membrane pumps and through gaba, not to mention whatever the heck the monoamines are doing. i think anyone would feel pretty leaden on your line up.

i know abstaining/tapering is never the most fun option, but personally i don't think i ever wanna mix meds (and my mind) up quite that deeply.

what the heck does a neuron do when you're hitting it with simultaneous agonists/antagonists?

best,
l8
> One of the things that happens to me when an MAOI is going to work well is that I experience near total insomnia. > Currently:
>
> Nardil (temporarily discontinued)
> nortriptyline 100mg
> Lamictal 150mg
> Topamax 100mg
> Abilify 10mg
>
>
> - Scott
>
>
> ------------------------------------
>
>
> > This is not news,HOWEVER just to share my experiance,as far as your common Maois,Parnate/Nardil/Liq deprenyl/emsam,
> >
> > One thing a new person migt want to consider before hand.
> >
> >
> > With exception of course,if you choose to go on one of these,take head of a very VERY likly chance you will devolp insomnia.
> >
> > Maois impact sleep,its a side effect that is simply extremly common.I personaly feel a person going on one might actualy benifit from this,how so?Well.....
> >
> > 1. Ive noticed that letting the drug actualy keep you up half,if not an entire night,will impact its therputic effect when taking it the next morning.
> >
> > Its only natural to think that a strong drug will have a different effect on a person in regards to the sleep they had.
> >
> > For example,coffee on a person who slept well usualy,(if they are a coffee drinker) will give them just enough nudge to awaken them to the degree of light stimulation.
> >
> > Now coffee on a person up all night,can create a maniac type of feel,look,i know ive seen people up all night down coffee,and well there eyes dilate and it looks as if they are on a speed ball,they look high,sometimes talking fast and acting very maniac.
> >
> > Now again i cant speak for everyone,however i found this to be true for myself.My maoi dose is decedied upon the amount of sleep i had.When im out of ambien and not sleeping,i respond very badly to parnate.
> >
> > I say this to possably give new users a head start,meaning perhaps prepare for this,speak to your docter and begin or have in place a sleep aid right from the start,as insomnia is usualy worse on maois at the start.
> >
> > I personaly would not worry to much about having to use a sleep aid on this level.I know people have beliefs on using sleep aids,HOWEVER understand that your not using it from left field,your using it to combat a serious side effect that can alter your success on the drug.
> >
> >
> > Last example is parnate can sometimes cause extreme fatigue,for me the actual best remedy has been a simple caffiene tab of 200 mg.
> >
> > My faimly looks at me like im crazy,and they are half right,alone id NEVER EVER want or be able to tolerate pure caffiene,HOWEVER using it to combat this fatique,well on these occasions the strong stimulation is barly appearent,and if it does its job the most that i feel is less fatigue from the parnate.
> >
> > Hopefully this makes sense,HAPPY NEW YEAR BTW,lets hope we see more success both here and everywhere and take a more steeper step forward aganist this horrid illness in 2007.
>
>


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URL: http://www.dr-bob.org/babble/20070101/msgs/719340.html