Posted by SLS on July 23, 2006, at 20:15:30
In reply to Re: what is my problem, posted by linkadge on July 23, 2006, at 16:38:01
> People with low SS verisons of the serotonin tranporter seem to fair poorly on SSRI's as a whole. They seem to have less thereaputic effect, create more severe and intollerable side effects in these individuals.
>
> It is possable that these people are depressed for other reasons altogether.
>
> It'd be nice to see if tianeptine was any more tollerable in this group.I did a quick search on Medline. I wanted to get an idea as to if there were any differences in baseline receptor densities in the SS SERT gene promotor variant. One study reported a global decrease in the number of 5-HT1a receptors in vivo brain of SS and LS, but not LL humans as assayed using PET scan.
I guess I really was backwards afterall.
Would you happen to know if any studies exist comparing 5-HTTLPR genotypes with levels of brain serotonin (post-mortem or otherwise)?
Another study of interest found that 5-HT1a binding was reduced in depression, but remained reduced after treatment with an SSRI. I guess my question would be whether binding was reduced further after treatment. The abstract didn't say.
Taken together, one might wonder if certain depressions result from reduced 5-HT1a binding secondary to SS and LS reduced SERT expression; the heterozygous being more common and amenable to treatment with SSRIs, while the homozygous being infrequent and less amenable to treatment with SSRIs and more susceptible to side effects with these drugs.
- Scott
poster:SLS
thread:669157
URL: http://www.dr-bob.org/babble/20060717/msgs/669831.html