Posted by Donna Louise on June 20, 2006, at 18:18:59
In reply to Re: Opiates » flmm, posted by linkadge on June 20, 2006, at 17:13:25
> Nobody here is suggesting that the euphoric feeling that opiates give at first is the antidepressant response.
>
> Some people actually feel euphoric on an antidepressant for the first little while, yet they can still continue to gain a theraputic effect once the euphoria has worn off.
>
> Take Nardil for instance. Many people notice that during the first month's usage, they feel euphoric. Though, even after this wares off many people continue to gain a theraputic effect against depression.
>
> Sure, there are going to be those who will continue to chase after that euphoric feeling (not mentioning any names).
>
> Some doctors are actually uncomfortable with the fact that MAOI's can often produce this initial effect, and won't prescribe them based on this.
>
> What we are trying to do here, is to find out if a person can take an opiate (beyond the timeframe to end euphoria) and still gain a theraputic effect at a constant dose.
>
> It seems that a growing number of patients claim this is the case. Are these patients junkies? If so, why would they remain satisfied at a fixed dose ?
>
> Sure the opiate receptors will adjust to the increased opiate agonism and downregulate, but so too will serotonin receptors in the presence of SSRI's.
>
> Who was it who posted a study not too long ago that said that morphine was equal to imipramine for treating melancholic depression at fixed doses, and relapse occured upon withdrawl of either agent.
>
>
> LinkadgeYes, you are right about the euphoria being possible with an ssri. The first tiime I took Paxil, I felt like I had taken a valium, which feels really good to me. The next time, I just felt really good. Both times my husband said I was acting like I was high although I didn't feel high the second time. These good feelings wore off of course. And I don't think it was med induced hypomania, it has not happened on any other drug.
donna
poster:Donna Louise
thread:651514
URL: http://www.dr-bob.org/babble/20060617/msgs/659386.html