Posted by Pops_1 on June 15, 2006, at 12:47:57
In reply to Re: EMSAM stronger than oral selegline » notfred, posted by Jakeman on June 15, 2006, at 1:22:28
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> > > b. MAO-A inhibition is what produces antidepressant efficacy
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> Other studies have shown that antidepressant efficacy for transdermal selelinge is provided at lower doses(6 mg) See below. Which may indicate that transdermal delivery has a stronger effect. Maybe its hitting both A and B. I don't know.You're right, it effective because it hits both A & B in the brain, but not the gut.
Transdermal Selegiline: The New Generation of Monoamine Oxidase Inhibitors
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=400"STS allows inhibition of brain MAO-A and MAO-B enzymes with reduced effects on GI MAO-A, thereby reducing the risk of possible interactions with tyramine-rich foods at therapeutic doses."
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thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/657256.html