Posted by Abby_L on June 3, 2006, at 6:23:57
In reply to Re: dexedrine/amphetamine absorption questions, posted by KayeBaby on June 3, 2006, at 1:27:29
This is how I understand it....
Affects of amphetamines are dependent on pH of stomach/intestinal tract and urine.
(Acidic=pH<7; alkaline/basic=pH>7)Stomach:
-Absorption is increased the higher/more alkaline the pH, and is decreased the lower/more acidic the pH.
Urine:
-Excretion is increased the lower/more acidic the pH, and is decreased the higher/more alkaline the pH.So, in regards to affects of amphetamines, foods/drinks that affect stomach and urinary pH:
acidic--> lesser effects
basic --> greater effectsAcidic agents include citrus, fruits and their juices, citric acid, and VITAMIN C. That is why Vit C is contraindicated, like you mentioned. Vit C in its natural form (l-ascorbic acid) is very acidic, definitely affects urinary pH.
Alkaline agents include many antacids, including baking soda, etc.I may be wrong, but this amphetamine pH-dependency does not apply to methylphenidate (Ritalin, Concerta) the same way. Its absorption effects have more to do with food ingestion, supposedly affecting only the absorption rate, not the total amount absorbed.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11587491&dopt=AbstractPossibly because food increases stomach acid, but that's just my guess.
poster:Abby_L
thread:651423
URL: http://www.dr-bob.org/babble/20060530/msgs/652267.html