Posted by pseudoname on April 22, 2006, at 15:43:57
In reply to Re: bupe is still out there, right? » pseudoname, posted by SLS on April 22, 2006, at 14:52:24
> How do you administer buprenorphine? Route, dosage, schedule?
In my 5th month on bupe, I take:
Subutex 0.5mg sublingual tablet (Actually, I put it between the cheek & the gum, like chaw. Too much saliva under the tongue.)
I take the 0.5mg once or twice a day, depending on how the day is going. First dose anywhere from 5 AM to 10 AM; second dose 6-8 hours later.
But I had to get up to 1.0 mg, 3 times a day (6AM, 11AM, 4PM), in the first weeks, before I got the antidepressant benefit. For whatever reason, I just need less now.
I just posted a list of reported bupe doses I compiled last year, but it needs updating. Other Babblers have recently reported very small effective doses. http://www.dr-bob.org/babble/20060417/msgs/635901.html
For anyone considering bupe, I think these may be good pages to show your doc. I hope he/she won't think a special DEA waiver is needed to Rx it for depression. (It isn't.)
When you first start, do NOT take more than 0.1 or 0.2mg a day. Larry Hoover gave me advice on taking such small doses: http://www.dr-bob.org/babble/subs/20051106/msgs/580668.html
The main reference is this:
• J. Alexander Bodkin, MD, Gwen L. Zornberg, MD, Scott E. Lukas, PhD, and Jonathan O. Cole, MD. "Buprenorphine Treatment of Refractory Depression." Journal of Clinical Psychopharmacology, 1995, 15, pp. 49-57 http://balder.prohosting.com/~adhpage/bupe.htmlI just posted my transcript of this study:
• H.W. Emrich. "Antidepressant Effects of Buprenorphine." Lancet, 1982, Sep 25; 2(8300): 709 http://www.dr-bob.org/babble/20060417/msgs/635895.htmlAnd there's this:
• Enoch Callaway. "Buprenorphine for Depression: The Un-adoptable Orphan [Editorial]." Biological Psychiatry. 1996 Jun 15; 39(12):989-90. http://www.dr-bob.org/babble/20010625/msgs/67856.html
poster:pseudoname
thread:635786
URL: http://www.dr-bob.org/babble/20060417/msgs/635902.html