Posted by SLS on April 14, 2006, at 6:27:10
In reply to How to shut down the catecholamine rush?, posted by blueberry on April 13, 2006, at 19:59:12
The clonidine and propranalol are interesting ideas. However, both have the potential to make depression worse. It still might be worth a try, though.
I know this is reaching, but you might have something going on with melatonin. Ideally, melatonin secretion by the Pineal Gland peaks at 2:00am and declines steadily for the balance of the night. Perhaps you are having too rapid a reduction in melatonin levels and are experiencing a sort of rebound. You might want to give melatonin a try to see how it affects you. If you find it helpful, but still inadequate, a new antidepressant named agomelatine should be available in Europe within a year. It stimulates melatonin receptors. If melatonin makes you feel worse, which is a possibility, then you need to rethink things. You should probably start off by taking melatonin at bedtime only.
Trimipramine is a tricyclic antidepressant that does not inhibit the reuptake of NE or 5-HT. It is known to improve sleep architecture in addition to being a good antidepressant. I imagine it would be well suited for you because you seem to fit the profile for the classic endogenous depression. This type of depression seems to be best treated with tricyclics. Response to antidepressants produces an increase in melatonin levels.
Still reaching...
- Scott
poster:SLS
thread:632837
URL: http://www.dr-bob.org/babble/20060412/msgs/632955.html