Posted by linkadge on March 29, 2006, at 19:45:57
In reply to Re: 5ht2 antagonists » linkadge, posted by zeugma on March 29, 2006, at 19:29:59
The downregulation of the 5-ht2 system seems to correlate to theraputic repsonce in many cases.
The question has been asked as to the exact mechanism of 5-ht2 downregulation. I personlly am under the impression that the greater the intrinsic 5-ht1a agonism, the greater the 5-ht2 downregulation.
I think that the 5-ht2 system mediates some responces to stress, and that downregulation reduces some of these responces.
Melatonin is another good agent to keep in mind. It has the ability to restore sensitivity to the 5-ht1a receptors.
http://biopsychiatry.com/melatemp.htm
Melatonin can actually sometimes cause depression. I think this is due to its anticonvulsant action. I had some depressive effects at first, but after a little while it actually seemed to be turning things around.
Linkadge
poster:linkadge
thread:626219
URL: http://www.dr-bob.org/babble/20060329/msgs/626306.html