Posted by chemist on December 8, 2005, at 19:05:59
In reply to Re: what are the receptors, neurological actions o » chemist, posted by iforgotmypassword on December 7, 2005, at 3:26:01
> yeah, i meant NE being a catecholamine... sorry, i suck when it comes to grammar. i seem to remember hearing of there being a balance or competition between ACh and catecholamines, especially with regards to ADs. does it explain some dry mouth people occassionally get on MAOIs as they are not directly anticholinergic?
hello there, chemist here...there is a proposed ``up and down'' for NE and ACh, respectively...if NE is up, mania...if ACh is up, depression...perhaps the muscarinic receptors - affinity for ACh - are to blame for the dry mouth...the nicotinic receptors are, in my opinion, less likely a culprit...and any number of 5-HT receptors can contribute to side effects such as dry mouth...the noradrenergic/cholinergic balance hypothesis includes a role for dopamine, too, and i believe there were experiments conducted in this light...in the end, i apologize for the non-response and encourage you to look up publications by Janowsky circa 1970...all the best, chemist
poster:chemist
thread:585697
URL: http://www.dr-bob.org/babble/20051203/msgs/587049.html