Posted by emme on October 29, 2005, at 7:47:34
In reply to Re: SLS - how's the trial? » emme, posted by SLS on October 29, 2005, at 2:26:32
> Hi Emme.
>
> > I've lost track.
> Me too.I think I have a secondary diagnosis of nobrainatall.
> > What are your impressions?
> I feel nothing positive.Rats.
> I am still hoping that there is some latency of effect that will kick in at some point post-discontinuation. It has been three days. I did experience a heck of an energy drain 36 hours after my last dose.I hope so.
> Given my high cortisol levelsHave you tried ketaconazole or any other cortisol-lowering drugs?
> how would someone with low cortisol and an atypical unipolar diathesis respond to it?
I spoke with an endocrinologist this summer who may try to treat some of my pdoc's treatment-resistant patients with cortisol-lowering drugs. He seemed to think that there was potential for a short course of a tiny dose for people with normal cortisol levels. As I understand it, even if cortisol levels are normal, if the daily variability is not normal, then the system might benefit from being reset. We didn't get to the question of treating people who have normal totals *and* normal diurnal variability.
He hadn't yet written the protocol, but was hoping to do it by the end of summer. I've had a response to Abilify, so I haven't been in contact with him again.
> Do you think the memantine is still helping you? When was the last time you attempted to increase the dosage to verify that it still had some therapeutic "punch" left in it?
Yeah, I think it is. I had dropped it down to 1.25 mg, actually. Then put it back up. I think I am a little better at the higher dose. 2.5 mg seems to be the max I can do.
I'm trying to find some sort of workable dosing of both memantine and abilify. With abilify, the insomnia and cold intolerance are problems. The insomnia might still improve. I don't know what I can do about the cold intolerance and it's getting cold outside! I can't concentrate on anything feeling so chilly. I'd forgotten about it. Last time I tried abilify, you suggested that it might be acting in a similar manner to apomorphine. If I knew it might ease up, it would help me be more patient.
Hang in there until the mifepristone (sp?) trial.
In the meantime, I hope you get your delayed reaction to the dexamethasone.em
poster:emme
thread:572867
URL: http://www.dr-bob.org/babble/20051024/msgs/572992.html